Bouling Group Co., Ltd

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Cyclohexanone: More Than a Building Block

Historical Development

Cyclohexanone traces its roots deep into the story of modern chemistry. Back in the early 20th century, researchers nailed down methods to isolate and synthesize this intermediate as petrochemical science advanced. Before nylon revolutionized clothing and industry, cyclohexanone didn't get much attention. Then came the mid-1900s. Production picked up heat because DuPont and IG Farben realized cyclohexanone serves as a doorway to adipic acid and caprolactam, two essentials for nylon production. This demand fired up investment, process tweaks, and plant construction. The humble ketone moved from lab curiosity to industrial staple as the world traded natural fibers for synthetics that owed their existence to this one molecule.

Product Overview

In the supply chain, cyclohexanone stands out as a transparent, oily liquid with a sharp, somewhat sweet odor—distinct but not unpleasant if you catch a quick whiff in a lab. Chemical firms ship it in tank trucks, drums, or bulk containers, labeling every batch with its purity and traceable lot number to meet regulatory demands and keep quality on track. Many see cyclohexanone as a simple solvent, but its role stretches far past that. Think of it as a reliable workhorse—sometimes undervalued until you see the mountain of products that depend on it.

Physical & Chemical Properties

Cyclohexanone registers a boiling point around 155 to 157°C and a melting point hovering near -31°C. It's heavier than water, with a density close to 0.95 g/cm³ at room temperature, and mixes easily with most organic solvents but barely with water. Chemists appreciate its reactivity—especially the carbonyl group, always ready to jump into reduction, oxidation, and condensation games. Flammability demands respect, and even brief handling calls for tight controls and clear heads.

Technical Specifications & Labeling

Manufacturers spell out typical specs for cyclohexanone: purity above 99.5%, water content under 0.1%, and low acidity. Labels include hazard symbols—flammable, irritant—as well as batch codes, CAS number (108-94-1), and global harmonization statements. The right labeling not only satisfies the letter of the law, it helps those who handle the product make informed decisions in the plant or on the loading dock.

Preparation Method

On the industrial scale, cyclohexanone usually comes from oxidation or hydrogenation. The main route uses cyclohexane, which meets air or oxygen in a controlled reactor—company chemists tune catalysts like cobalt or manganese to hit optimal conversion without overdoing things and turning the product into acids. The other popular route starts with phenol, producing cyclohexanone alongside cyclohexanol from benzene via hydrogenation, then separating and purifying the fuels for nylon. Both methods run best with skilled operators watching for byproduct buildup, temperature excursions, and the tight window between yield and decomposition.

Chemical Reactions & Modifications

Cyclohexanone’s carbonyl group opens the door to plenty of chemical upgrades. Reduction leads to cyclohexanol, a staple for nylon 6 and nylon 66. Oxidation pushes toward adipic acid, another nylon building block. Reacting with various amines forms intermediates for pharmaceuticals and pesticides; with formaldehyde, it gives resins found in thousands of adhesives and coatings. Every reaction in the book gets tested to stretch value and refine utility, often by blending old tricks with new catalysts or green reagents to lower environmental footprints.

Synonyms & Product Names

Cyclohexanone turns up in catalogs under several names. It goes by pimelic ketone, hexanone, or eigene names like Cyklohexanon and Ketohexamethylene. Distributors sometimes bundle it as “oxocyclohexane solvent” or “Nylon intermediate K,” giving clues about grade and end-use. For recordkeeping, the CAS registry number does most of the heavy lifting in avoiding mix-ups between suppliers and buyers.

Safety & Operational Standards

Working with cyclohexanone takes vigilance. The material sparks and starts fires at just 44°C, so plant teams separate hot zones, keep air concentrations below 25 ppm, and use explosion-proof equipment. Splashing skin burns quickly, and inhaling vapors puts eyes, throats, and lungs at risk—respirators, goggles, and gloves become second nature. Safety Data Sheets, emergency showers, and clear spillage drills can turn small accidents into routine cleanups instead of disasters. Good training probably prevents more injuries than even the best ventilation fans. Community right-to-know laws and modern monitoring demand regular audits and reporting. The public expects it, insurers require it, and smart operators don't cut corners.

Application Area

Most of the world’s cyclohexanone still winds up as an intermediate for nylon 6 and 66—key to fibers, plastics, tire cords, and high-strength films. A good chunk sweeps into the solvent trade, tackling paints, varnishes, pesticides, printing inks, adhesives, and degreasers. Tooling and die industries use cyclohexanone in metal cleaning formulas. Rubber manufacturers pick it for custom synthetics. Even perfumers turn to cyclohexanone derivatives to dial in unique notes. In labs, students and researchers prize it for its clean reactions and reliable outcomes, finding ways to rework or reuse it in green chemistry projects aimed at cleaner production cycles.

Research & Development

Universities and chemical makers keep hunting for catalysts that boost yield, shrink byproducts, and work at lower pressures and temperatures. The push toward bio-based feedstocks gets scientists testing if cyclohexanone can trace new roots from renewables or waste streams. Green chemistry collaborations between public agencies and industrial giants target less energy-intensive processes and closed-loop cycling. Analytical labs track trace impurities at ever-lower thresholds, so new analytical methods surface every year to keep up with regulatory tightening. The pace of research reflects the hunger for better safety, cleaner air, and reduced lifecycle emissions without sacrificing output.

Toxicity Research

Toxicologists know cyclohexanone isn’t a benign substance. Acute exposures cause dizziness, headaches, and nausea, while long-term contact can stress liver and kidney function. The U.S. National Institute for Occupational Safety and Health notes irritation and central nervous system impacts show up at relatively low concentrations. While not known as a carcinogen, this molecule doesn’t get a free pass—industry-supported studies look for ways to limit fugitive emissions and automate loading to keep hands and lungs away from direct exposure. Routine biological monitoring, coupled with air sampling, gained ground in the ‘90s and continues to underpin workplace controls today.

Future Prospects

The world’s hunger for durable plastics and fibers doesn’t look like it’s slowing down, though substitutes for cyclohexanone-based nylons keep inching forward. Demand for greener, renewable-sourced cyclohexanone will grow as investors and buyers push for transparent supply chains. Next-generation processes claim fewer greenhouse gases and less waste, making use of oxygen or hydrogen in compact, modular reactors. Digital twins and data-driven maintenance optimize runs, pushing efficiency closer to the edge. Legislators, environmental groups, and downstream users all pull hard for smarter, safer production, knowing there’s no appetite for old-style spills or legacy contamination. In the chemical world, the future belongs to those who tough out the details and marry cost with conscience, and cyclohexanone, both familiar and adaptable, remains in the thick of things.



What is cyclohexanone used for?

Where Cyclohexanone Shows Up Most

Take a closer look at products with nylon in your home. Odds are cyclohexanone played a role in their journey to your hands. This clear, colorless liquid often pops up in stories about chemical manufacturing, and for a good reason. Nylon, the very same fiber woven into backpacks, toothbrush bristles, carpets, and automobile parts, relies on cyclohexanone almost like bread relies on flour. Its main job: serving as a starting material to make caprolactam, the core building block for nylon 6.

Bigger Uses Beyond Just Nylon

Factories also lean heavily on cyclohexanone for making other valuable chemicals. It marks a stop along the path to adipic acid, where it helps create strong, flexible plastics and synthetic rubbers. I’ve spent time on the floor of a polymer plant, and chemical engineers measure their days in careful steps that include solvents like this. The workhorse quality of cyclohexanone keeps materials sturdy, costing less and lasting longer for countless end users.

Behind-the-Scenes as a Solvent

Painters, shoemakers, and cleaners across fields once found cyclohexanone in their toolkit. It quickly dissolves resins, fats, waxes, and more. That fast-acting property means it’s in the recipe for many paint removers and coatings. Some adhesives and inks feature cyclohexanone for this same reason. At times, I’ve peeled labels from glass or fixed a loose shoe sole, not realizing the quick-bonding glue likely owes its grip to this compound.

Health and Environmental Concerns

Getting familiar with cyclohexanone opens eyes to safety. It evaporates easily and can irritate skin and lungs if workers don’t follow strict handling procedures. In my time at manufacturing sites, protective gloves and eye gear became as important as the chemicals themselves. Regulations step in for good reason, with OSHA and similar bodies capping exposure and demanding careful tracking of workplace air quality. Reports link overexposure to headaches and, with long-term contact, more worrying health effects.

Seeking Safer Solutions and Greener Practices

Pressure from environmental watchdogs and consumers pushes industries to seek out alternatives. Companies started reworking old processes, looking for tighter controls to capture vapors and safer substitutes that won’t damage ozone or threaten health. Engineers pour resources into “green chemistry”—rethinking solvent choices to shrink pollution and waste. On one project, colleagues switched cleaning solutions to water-based options, cutting out not just cyclohexanone but several other risky chemicals. Not every replacement comes easy, but progress does happen one tested solution at a time.

Moving Forward with Informed Choices

No one talks about cyclohexanone at the dinner table, but it sits behind much of everyday life’s plastic and fiber. Being aware helps consumers, workers, and business leaders make smarter choices. Tracking safety standards and supporting research keeps health and the environment at the center of progress. Cyclohexanone’s story serves as a reminder: behind every manufactured good lies a careful chain of decisions balancing utility, cost, safety, and responsibility.

Is cyclohexanone hazardous to health?

Everyday Encounters with Cyclohexanone

Cyclohexanone shows up as a clear, oily liquid, carrying a distinct odor, showing up in places no one expects—industrial plants, painting shops, cleaning supply rooms. Factories use it for making nylon, plastics, and paints. Workers in these environments deal with its vapors and liquid forms more than most people realize.

Health Risks That Shouldn’t Be Overlooked

Anyone around cyclohexanone for work, especially without good ventilation or proper gear, feels its impact. Even in small doses, breathing its vapor brings headaches, nausea, and dizziness. Sometimes the symptoms pass quickly, but days spent with strong fumes are different. Once, after a stint at an auto body shop, I noticed coworkers complaining about burning eyes and dry throats every time the room filled with paint thinner. I figured this was normal, until one guy fainted right in front of the paint booth—and he’d only been there a couple of weeks.

The CDC says short-term exposure irritates eyes, nose, and throat. Skin absorbs cyclohexanone fast, causing redness and, after long contact, blistering. If someone gets too much of this stuff on their skin or breathes too much, central nervous system effects follow—confusion, weakness, sometimes even unconsciousness. One study from the European Chemicals Agency points out that repeated exposure brings even worse effects, like kidney and liver damage. They mark cyclohexanone as a substance needing close handling.

Watching Workers’ Health in the Real World

People who work with cyclohexanone daily face tough choices. Some ignore the risk and skip gloves or masks, convinced they can “handle it.” The problem grows in older factories or constructions sites where ventilation took a back seat to cost savings. It’s not surprising when reports of nausea or severe headaches multiply during busy production weeks. That’s not a coincidence—it’s the cost of missing safety priorities.

Not everyone knows these dangers. Manufacturers often bury warnings in long safety data sheets few people read. Yet, organizations from OSHA to WHO list cyclohexanone as a hazardous chemical. OSHA’s standards put an airborne exposure ceiling at 25 parts per million over an eight-hour workday. Yet, in cramped, poorly ventilated spots, I’ve seen readings that blow right past that limit. Some supervisors wave off complaints, blaming colds or allergies instead of checking air monitors.

Better Habits Lead to Better Health

Clear training, honest conversations, and simple steps make a huge difference. Workers need the right gloves, goggles, and respirators. Break times in fresh air aren’t just a perk—they keep everyone healthier. Facilities with serious ventilation systems cut health complaints way down.

It’s not just about keeping the company out of trouble. Healthy workers get the job done without missing days for illness. Costs drop, output improves, and anxiety drops across the floor when people know they’re not breathing in poison or risking long-term illness with each shift. Even small shops and warehouses can afford improvements—fans, exhaust vents, and spill kits go a long way. Owners who do it right see fewer compensation claims and lower turnover. Workers talk about those jobs with respect.

Information and Accountability

Cyclohexanone has a role in a modern, industrial world, but only when people show respect for its risks. Informed workers with real equipment and regular check-ins stay safe. I’ve seen the difference up close. That’s why anyone using cyclohexanone deserves honest answers and a safe workplace, not just a paragraph in a binder gathering dust.

What is the chemical formula of cyclohexanone?

Understanding Cyclohexanone

Cyclohexanone carries the formula C6H10O. This single line says a lot about the substance, although it can feel like chemistry class all over again. So, what does this formula tell us? There are six carbon atoms, ten hydrogens, and one oxygen atom in each molecule. The layout helps anyone picturing the substance's structure, a six-sided carbon ring—like the more famous benzene—but with a twist: the ring holds a double-bonded oxygen. That single tweak makes cyclohexanone a ketone and gives it different properties from something like cyclohexane or benzene.

Practical Impacts: Why the Formula Isn’t Just Trivia

The chemical formula shapes how cyclohexanone works in the real world. A big chunk of nylon production comes down to this single compound. Most people don't realize that about 95% of all cyclohexanone goes toward nylon-6 and nylon-6,6. No chemical factories building those fibers? No sturdy swimwear, seat belts, or carpet backing. The formula reveals why this molecule sits in the middle of so many daily products. Chemically speaking, the ketone group (that O stuck to a carbon by a double bond) allows factory chemists to carry out certain reactions that wouldn't work on just any ringed hydrocarbon. Without that carbonyl oxygen, nylon synthesis stalls.

Real Risks and Smart Handling

Getting too close to cyclohexanone without care gets risky. Breathing vapors or touching it can make a worker dizzy or even result in burns. It smells a bit like acetone but sharper. That odor tips off the nose before the body starts feeling it, but it's not a warning to ignore. U.S. agencies like OSHA set strict rules about handling, and for good reason. Cyclohexanone dissolves fats and oils easily because of its polar group. This property allows it to sneak past the skin barrier and carry other chemicals with it, making gloves and goggles a must.

Chemical formulas also steer the conversation around waste. Cyclohexanone can leak from factories into rivers if pipes break or tanks rust. With that oxygen atom in there, bacteria in water might eat it up faster than other cycloalkanes, but contamination risks don't vanish just because of a helpful property. Studies from the European Chemicals Agency point out cyclohexanone’s moderate toxicity to fish and aquatic insects. Anyone treating wastewater from chemical plants needs to know this exact formula—not just so the paperwork checks out, but to pick water treatments that destroy or filter the right molecule.

Pushing Safety and Sustainability

Safer dyes and plastics rest on understanding the basics, starting with formulas. Some companies develop alternative catalysts so nylon production relies on less energy or milder chemicals. Students who work out that C6H10O stands apart from what they see in high school chemistry labs get a front-row look at where lab work meets world need. Future steps aim for green chemistry routes—creating cyclohexanone starting with renewable sources such as biomass, which could cut down pollution at the source and blend smarter choices into everyday manufacturing.

How should cyclohexanone be stored?

Why Cyclohexanone Can’t Be Handled Like Just Any Chemical

Cyclohexanone has a sharp, sweet smell that lingers, but it’s the invisible dangers that really matter. As someone who spent several years working in a coatings lab, watching coworkers drop their guard with solvents always set me on edge. This colorless liquid evaporates fast and catches fire easily at room temperature. Leave a bottle carelessly near a heat source and you risk more than a nasty odor – you might trigger a serious fire. Inhaling the fumes, especially without proper ventilation, leads to headaches, dizziness, and even damage to the central nervous system. Repeated skin contact causes cracking and painful irritation, so even simple storage choices shape both safety and long-term health for everyone on site.

The Storage Routine: Small Steps Make a Big Difference

A chemical with a flash point around 44°C belongs far away from careless handling. Flammable cabinets rated to withstand intense heat for at least 30 minutes can buy lifesaving time in a fire; that’s not just regulation, that’s experience talking. After a small fire almost spread in our storeroom because a bottle of cyclohexanone sat exposed on a wooden shelf, our safety officer installed new lockers with tight seals and self-closing doors. Old habits die hard, but regular fire drills and visible reminders about proper storage got everyone on board.

Rooms that store cyclohexanone need steady temperatures and good ventilation. Heat and sunlight push more vapor into the air and raise risk sharply, so it makes sense to pick a spot without direct light and without temperature swings. Store it only in approved metal containers with clear, durable labels. Glass breaks under stress; thin plastics let vapors through. Well-labelled containers leave no guessing for the night shift or new hires. I remember confusion once during an emergency clean-up because someone used a faded label – never worth the risk.

Shortcuts Create Long-Term Trouble

Mixing cyclohexanone storage with acids, bases, or oxidizers causes dangerous reactions. I’ve seen hurried staff accidentally place incompatible drums side by side, thinking short-term ease beats long-term planning. Keeping safety data sheets within arm’s reach changes the culture – staff refer to them more often, and old timers help new staff understand why chemicals must stay separated. Regular inventory checks have caught expired or leaky containers before they could become a bigger hazard.

Solutions: Building Habits, Not Just Rules

Training sessions seem boring at first, but once people hear real-world stories about solvent fires or poisoning, reality hits home. Use signage that speaks plainly and post it near every storage zone. Over time, safety improvements – spill trays under shelves, non-sparking tools, and careful record keeping – become as normal as locking the lab door at night. Encourage everyone to call out unsafe practices without hesitation. In my experience, teams that talk openly about risks respond faster and stick to safe routines.

Fire suppression systems and chemical safety showers sound expensive, yet the cost doesn’t compare to what one accident might do to a team or business. Cyclohexanone might look harmless, but small steps – approved cabinets, good ventilation, vigilant housekeeping, and strong training – protect both people and the bottom line. Those details matter, every single day.

What is the difference between cyclohexanone and cyclohexanol?

Understanding Two Very Different Chemicals

Cyclohexanone and cyclohexanol share much of the same DNA on paper. Both stem from cyclohexane, and both show up often in manufacturing conversations, especially when talking about nylon. But skim past the chemical drawings and reach beyond the abstract: these two substances behave differently and play wildly different roles in real-life industries.

What Sets Them Apart?

Cyclohexanone wears the badge of a ketone; cyclohexanol counts as an alcohol. That small difference—a double-bonded oxygen for cyclohexanone versus a hydroxyl group for cyclohexanol—changes not just the molecule’s chemistry, but its usefulness outside the lab.

Cyclohexanone acts as a common building block for making nylon-6 and nylon-6,6. It’s used chiefly in making adipic acid, which forms the backbone of nylon’s fiber. Factories produce it in large volumes, and you’ll find it in things like paint removers and lacquers. Cyclohexanol, on the other hand, sees use as both a precursor to cyclohexanone and as a high-boiling solvent for things like perfumes and some plasticizers. Neither turns into something you’d ever want near your food or drink, but one can smell slightly sweet, the other sharply pungent.

Health and Safety Aspects

Anyone who’s worked around these chemicals knows the importance of respecting their hazards. Cyclohexanone can release vapors that, in high concentrations, irritate the eyes and respiratory tract. Proper ventilation and gloves become job essentials, not recommendations. Cyclohexanol doesn’t lag far behind—extended exposure brings dizziness and headaches. Both require careful handling, but cyclohexanone tends to get the stricter warnings because of its flammability and higher volatility.

Why the Difference Matters in Industry

I’ve watched plant operators sweat over cyclohexanone production during hot summer months. The volatility means losses in the air and risks nobody wants. Because of this, the specific difference between a ketone and an alcohol changes the types of safety gear, storage type, and environmental controls you see in a facility. Fail to pay attention, and leaks happen. That’s not just lost product—it’s a blown safety record, a regulatory headache, and sometimes a trip to the emergency room.

Making Choices With Knowledge

Down in the trenches, these subtle differences mean certain plant setups and distribution methods suit one chemical, rarely both. Industry standards don’t just exist to fill up binders—they reflect hard lessons learned from mistakes and accidents. Years back, I saw a batch tank mistakenly loaded with cyclohexanone instead of cyclohexanol. It upset the process, forced costly cleanup, and reminded everyone why clear labeling and chemical training matter even in high-pressure situations.

Solutions and Best Practices

Experience teaches the importance of individualized safety assessments for each substance in a process. Storing cyclohexanone in tightly sealed drums with explosion-proof vents lowers flammability risks. Designing process flows with built-in checks and redundancies helps prevent mix-ups. Training staff to recognize odors, know proper protective habits, and understand chemical differences turns them from potential victims into active preventers of accidents. Together, these practical steps create workplaces where both cyclohexanone and cyclohexanol contribute safely to production.

Cyclohexanone
Cyclohexanone
Cyclohexanone
Names
Pronunciation /saɪ.kloʊˈhɛk.səˌnoʊn/
Identifiers
CAS Number 108-94-1
Beilstein Reference 1204270
ChEBI CHEBI:17854
ChEMBL CHEMBL415
ChemSpider 8077
DrugBank DB06714
ECHA InfoCard 03c1a6e6-7e6b-429f-871d-e2afc9cda705
EC Number 206-01-3
Gmelin Reference 613252
KEGG C06588
MeSH D003460
PubChem CID 7967
RTECS number GV7875000
UNII X8D5I17MQ3
UN number UN1915
CompTox Dashboard (EPA) DTXSID4020737
Properties
Chemical formula C6H10O
Molar mass 98.15 g/mol
Appearance Colorless to pale yellow liquid with a peppermint-like odor.
Odor Peppermint-like
Density 0.947 g/cm³
Solubility in water Moderately soluble
log P 1.23
Vapor pressure 0.9 kPa (at 20 °C)
Acidity (pKa) 20.7
Basicity (pKb) 15.10
Magnetic susceptibility (χ) -7.90 × 10⁻⁶ cm³/mol
Refractive index (nD) 1.450
Viscosity 2.02 mPa·s (25 °C)
Dipole moment 3.87 D
Thermochemistry
Std molar entropy (S⦵298) 186.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -238.7 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -3540 kJ·mol⁻¹
Hazards
GHS labelling GHS02, GHS07
Pictograms GHS02,GHS07,GHS08
Signal word Danger
Hazard statements H226, H302, H315, H319, H332
Precautionary statements P210, P261, P280, P305+P351+P338, P312, P337+P313
NFPA 704 (fire diamond) 2-3-1
Flash point 44°C (111°F)
Autoignition temperature 420 °C
Explosive limits 1.1–9.4%
Lethal dose or concentration LD50 oral, rat: 1620 mg/kg
NIOSH K0275
PEL (Permissible) 50 ppm
REL (Recommended) 25 ppm
IDLH (Immediate danger) 700 ppm
Related compounds
Related compounds Oxocyclohexane
Pimelic acid
Caprolactam
Cyclohexanol
Adipic acid
Phenol