MSDS for Cyclohexylamine

1. Identification

Product Name: Cyclohexylamine
Chemical Formula: C6H11NH2
CAS Number: 108-91-8
Synonyms: Aminocyclohexane, Hexahydroaniline, PCA
Recommended Use: Intermediate in chemical synthesis, corrosion inhibitor, rubber accelerator, water treatment chemical
Manufacturer Information: Supplier name, address, contact number
Emergency Contact: CHEMTREC, emergency response number

2. Hazard Identification

GHS Classification: Flammable liquid (Category 3), Acute toxicity oral/dermal/inhalation (Category 3), Skin corrosion (Category 1B), Serious eye damage (Category 1)
Label Elements: Flame, Skull and crossbones, Corrosive pictograms
Signal Word: Danger
Hazard Statements: Flammable liquid and vapor. Toxic if swallowed, in contact with skin or inhaled. Causes severe skin burns and eye damage.
Precautionary Statements: Avoid breathing vapors/mist. Wear protective gloves, clothing, eye and face protection. Keep container tightly closed.
Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Effects of Exposure: Headache, nausea, respiratory tract irritation, burns, blurred vision, kidney effects, CNS depression

3. Composition / Information on Ingredients

Chemical Name: Cyclohexylamine
Concentration: 99-100%
CAS Number: 108-91-8
Impurities/Decomposition Products: Trace amines, water, residual solvents may occur from manufacturing process

4. First Aid Measures

General Advice: Remove sources of contamination. Move victim to fresh air. Take MSDS to medical personnel.
Inhalation: Move to fresh air. If breathing is difficult, provide oxygen. Give artificial respiration if not breathing.
Skin Contact: Remove contaminated clothing. Wash thoroughly with soap and water for at least 15 minutes. Seek medical help if irritation persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do.
Ingestion: Rinse mouth. Do not induce vomiting unless instructed by poison center. Never give anything by mouth to an unconscious person.
Symptoms: Burning sensation, difficulty breathing, cough, redness, pain, possible delayed effects. Medical attention required.

5. Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Special Hazards: Vapors are heavier than air and may travel to ignition source. Combustion produces toxic fumes: nitrogen oxides, ammonia, carbon monoxide, carbon dioxide.
Protective Equipment: Full firefighting turn-out gear, self-contained breathing apparatus
Firefighting Instructions: Use water spray to cool intact containers. Remove containers from area if possible without risk.
Explosion Data: Vapors may form explosive mixtures with air, flashback possible.
Flash Point: 28°C (82°F) (Closed cup)
Auto-ignition Temperature: 293°C (559°F)
Flammable Limits in Air: Lower 1.3%, Upper 9.4%

6. Accidental Release Measures

Personal Precautions: Evacuate unnecessary personnel. Wear chemical-resistant gloves, goggles, impervious clothing, respiratory protection.
Environmental Precautions: Prevent run-off to sewers, soil, waterways. Alert authorities if contamination occurs.
Containment/Cleanup: Ventilate area. Eliminate all ignition sources. Absorb with inert material (sand, earth, vermiculite), then shovel into clean, dry containers for disposal. Wash spill area after material pickup. Dispose according to regulations.
Spill Kit Components: Absorbent pads, neutralizing agents, sealed waste containers, PPE

7. Handling and Storage

Handling: Use local exhaust or general dilution ventilation. Avoid contact with skin, eyes, and clothing. Do not breathe fumes. No smoking. Keep away from heat, sparks, open flames.
Storage Conditions: Store in cool, dry, well-ventilated area. Keep container tightly closed and away from incompatible substances (strong acids, oxidizers, halogens). Use explosion-proof equipment. Ground and bond containers.
Incompatibilities: Acids, acid chlorides, acid anhydrides, oxidizing agents, chloroformates
Packaging: Use containers resistant to amine corrosion—steel drums with inner lining, tightly fitted lids.
Special Requirements: Segregated storage for flammable and corrosive substances, regular inspection for leaks.

8. Exposure Controls / Personal Protection

Occupational Exposure Limits: ACGIH TLV: 10 ppm (skin), OSHA PEL: 10 ppm (time-weighted average)
Engineering Controls: Use chemical fume hood. Provide mechanical ventilation for confined spaces. Install explosion-proof equipment where necessary.
PPE: Chemical splash goggles, face shield, impervious gloves (nitrile, neoprene), flame-resistant lab coat, closed-toe shoes, respiratory protection if vapor formation exceeds permissible limits.
Hygiene Measures: Wash hands after handling. Remove and wash contaminated clothing before reuse. Do not eat, drink, or smoke near chemicals.

9. Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Strong, fishy, ammoniacal
Odor Threshold: 0.02 ppm
pH (10% Solution): Strongly alkaline (~12)
Melting Point: -17°C (1.4°F)
Boiling Point: 134.5°C (274°F)
Flash Point: 28°C (82°F)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Vapor Pressure: 11 mmHg (20°C)
Vapor Density: 3.6 (air = 1)
Relative Density: 0.864 (water = 1)
Water Solubility: Miscible
Partition Coefficient (n-octanol/water): 1.96
Auto-ignition Temperature: 293°C (559°F)
Decomposition Temperature: Not available
Viscosity: 2.18 mPa·s at 20°C

10. Stability and Reactivity

Chemical Stability: Stable under recommended storage conditions. Sensitive to moisture and light.
Reactivity: Highly reactive with oxidants, acids, acid chlorides and anhydrides. Can react violently on contact.
Hazardous Decomposition: Toxic fumes—nitrogen oxides, ammonia, hydrogen cyanide in fire.
Polymerization: Does not polymerize
Conditions to Avoid: Heat, flames, sparks, incompatible materials, exposure to air and moisture

11. Toxicological Information

Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity Data: LD50 oral (rat): 156 mg/kg; LD50 dermal (rabbit): 277 mg/kg; LC50 inhalation (rat, 4h): 1.8 mg/L
Local Effects: Severe eye, skin and respiratory tract burns
Chronic Effects: Prolonged or repeated exposure can cause liver, kidney, CNS damage. May aggravate pre-existing conditions.
Sensitization: Not classified as a sensitizer
Mutagenicity/Carcinogenicity: Not listed as a known carcinogen. No mutagenic effects in standard tests.
Other Effects: Nausea, vomiting, headache, dizziness, CNS depression, possible methemoglobinemia

12. Ecological Information

Ecotoxicity: Highly toxic to aquatic life. LC50 (fish, 96 h): 44-46 mg/L. Highly toxic to daphnia and algae.
Persistence/Degradability: Moderately biodegradable in water and soil.
Bioaccumulation Potential: Low. Log Kow: 1.96
Mobility in Soil: High. Soluble and mobile, can leach into waterways.
Other Adverse Effects: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environment. Volatilizes quickly from water.

13. Disposal Considerations

Methods of Disposal: Incinerate at licensed facility. Absorb in inert material prior to incineration.
Local Regulations: Dispose in accordance with local, state, and federal requirements. Do not allow to enter drains or waterways.
Container Disposal: Rinse thoroughly, puncture, and dispose at approved site.
Special Precautions: Handle empty containers with care. May contain hazardous residues.

14. Transport Information

UN Number: UN2357
UN Proper Shipping Name: Cyclohexylamine
Transport Hazard Class: 3 (Flammable liquid), 8 (Corrosive)
Packing Group: II
Labeling Requirements: Flammable Liquid, Corrosive
Transport by Road (ADR/RID): Class 3, Code F1, Tunnel restriction code D/E
Transport by Air (IATA): Prohibited in passenger aircraft above threshold. Cargo only.
Marine Transport (IMDG): Marine pollutant, EmS F-E, S-C
Special Transport Precautions: Secure containers. Segregate from foodstuffs, oxidizers, acids.

15. Regulatory Information

Inventory Status: Listed on TSCA (US), EINECS/ELINCS (EU), DSL (Canada), AICS (Australia), ENCS (Japan), PICCS (Philippines), KECI (Korea), NZIoC (New Zealand)
SARA Title III: Immediate/acute health hazard, Fire hazard
RCRA Status: U193 hazardous waste
Right-to-Know: Subject to reporting in Massachusetts, New Jersey, Pennsylvania
Regulatory References: OSHA Hazard Communication Standard, EU CHIP, CLP Regulation, REACH, Canadian WHMIS