Material Safety Data Sheet (MSDS) for Ethylenediamine (EDA)

Identification

Product Name: Ethylenediamine
Chemical Formula: C2H8N2
Synonyms: 1,2-Diaminoethane, EDA
CAS Number: 107-15-3
Recommended Use: Intermediate for chemical synthesis, resins, chelating agents, pharmaceuticals
Supplier Details: Manufacturer contact information, emergency telephone number, address, and email for support
Emergency Numbers: National fire, poison, and spill hotlines relevant for quick assistance in emergencies involving EDA

Hazard Identification

GHS Classification: Flammable liquid—Category 3; Acute toxicity (oral, dermal, inhalation)—Category 4; Skin corrosion—Category 1B; Serious eye damage—Category 1; Specific target organ toxicity—Category 3 (respiratory tract irritation)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; Harmful if swallowed, inhaled, or on skin; May cause respiratory irritation; Flammable liquid and vapor
Pictograms: Flame, Corrosive, Exclamation mark
Precautionary Statements: Avoid breathing vapor; Use only in well-ventilated areas; Wear protective gloves, clothing, eye, and face protection; Keep away from heat, sparks, open flames; Store locked up; Wash thoroughly after handling; Seek medical advice if feeling unwell

Composition / Information on Ingredients

Chemical Name: Ethylenediamine
Content: 100%
Identification Numbers: CAS No. 107-15-3, EC No 203-468-6
Impurities: None known to significantly impact hazard profile of product
Molecular Weight: 60.10 g/mol

First Aid Measures

Inhalation: Move affected person to fresh air immediately; keep comfortable for breathing; oxygen or artificial respiration if needed; seek medical help
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with water for at least 15 minutes; get immediate medical attention; launder clothing before reuse
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, lifting eyelids to flush thoroughly; remove contact lenses if present; seek medical advice promptly
Ingestion: Do not induce vomiting; rinse mouth with water; never give anything by mouth to an unconscious person; immediate medical assistance required
Symptoms / Effects: Burning sensation, cough, shortness of breath, severe skin or eye irritation, possible respiratory tract inflammation, gastrointestinal upset on ingestion

Fire-Fighting Measures

Suitable Extinguishing Agents: Alcohol-resistant foam, dry chemical powder, carbon dioxide, water spray (do not use direct water jet)
Fire Hazards: Vapors may form explosive mixtures with air; thermal decomposition may release toxic fumes including nitrogen oxides, carbon oxides, ammonia
Protective Equipment: Firefighters require self-contained breathing apparatus with full-face mask, chemical protective clothing, gloves, and boots
Special Precautions: Containers may rupture due to pressure build-up; use water to cool exposed containers; move containers away from fire area if safe
Hazardous Combustion Products: Ammonia, nitrogen oxides, carbon monoxide, carbon dioxide

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel; ventilate area; prevent inhalation of vapors; use protective equipment—gloves, goggles, respirators
Environmental Precautions: Keep product out of sewers, waterways, soil; notify relevant authorities if product enters environment in significant amount
Containment Methods: Stop leak if safe; contain spill with non-combustible absorbent material (sand, earth, vermiculite); prevent run-off to drains
Clean-up Methods: Collect residue in labeled containers for disposal; rinse area with water; avoid release of vapors during clean-up; decontaminate tools and equipment thoroughly

Handling and Storage

Precautions for Safe Handling: Use only in well-ventilated areas; avoid inhaling vapor; do not allow contact with skin, eyes, or clothing; maintain proper labeling on containers
Handling Advice: Ground and bond containers; use spark-proof tools; take precautions against static discharge
Storage Requirements: Store in tightly closed containers; keep in cool, dry, and well-ventilated area; separate from acids, oxidizers, and chlorinated compounds; store away from ignition sources and moisture
Special Considerations: Avoid contamination; inspect containers regularly; keep storage area equipped with spill containment and emergency shower/eye wash stations

Exposure Controls and Personal Protection

Occupational Exposure Limits: ACGIH TLV 10 ppm (25 mg/m³), OSHA PEL 10 ppm (25 mg/m³)
Engineering Controls: Local exhaust ventilation, process enclosures, general mechanical ventilation
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile, neoprene), splash-proof safety goggles, full-face shield, protective suit, closed-toe shoes, respiratory protection for high vapor concentrations or insufficient ventilation
Hygiene Measures: Wash hands before eating, drinking, or smoking; remove contaminated clothing and wash before reuse
Environmental Controls: Prevent release into environment; use closed systems or proper exhaust where feasible

Physical and Chemical Properties

Appearance: Colorless to pale yellow clear liquid
Odor: Ammoniacal
Odor Threshold: Low; strong, pungent
pH: Strongly alkaline
Melting Point: 8.5°C (47°F)
Boiling Point: 116°C (241°F) at 101 kPa
Flash Point: 38°C (100°F) closed cup
Evaporation Rate: Not available
Flammability: Flammable liquid
Explosive Limits: Lower: 2.7% — Upper: 16.0% (v/v in air)
Vapor Pressure: 12 mmHg @ 25°C
Vapor Density: 2.07 (air = 1)
Relative Density: 0.898 g/cm³ @ 20°C
Solubility: Miscible in water, ethanol, ether
Partition Coefficient: log Pow -2.04
Auto-Ignition Temp: 385°C (725°F)
Decomposition Temp: Not determined
Viscosity: 1.12 mPa·s at 25°C

Stability and Reactivity

Chemical Stability: Stable if stored under recommended conditions; easily absorbs moisture and carbon dioxide from air
Incompatible Materials: Strong acids, acid chlorides, acyl halides, oxidizing agents, copper, brass, and other alloys
Hazardous Reactions: May react violently with acids; forms explosive compounds with chlorinated hydrocarbons and nitrosating agents
Decomposition Products: Toxic gases including nitrogen oxides, ammonia, carbon oxides during fire or extreme heat
Polymerization: Hazardous polymerization unlikely under normal handling and storage

Toxicological Information

Exposure Routes: Inhalation, ingestion, skin, and eye contact
Acute Toxicity (oral, rat): LD50 1,200 mg/kg
Acute Toxicity (dermal, rabbit): LD50 640 mg/kg
Acute Toxicity (inhalation, rat): LC50 14 mg/L (4 h)
Serious Eye Damage/Irritation: Causes serious burns and possible permanent injury
Skin Corrosion/Irritation: Severe burns on contact—penetrates skin
Respiratory/Skin Sensitization: Can cause allergies from repeated or prolonged exposure
Chronic Effects: Repeated contact can cause dermatitis, respiratory irritation
Carcinogenicity: Not classified as a human carcinogen
Mutagenicity: No significant evidence in available studies
Other Health Issues: No evidence for teratogenic or reproductive toxicity at standard workplace exposures

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms, acute and long-term effects
Toxicity to Fish (LC50): 115 mg/L (96 hr, Pimephales promelas)
Toxicity to Daphnia (EC50): 16 mg/L (48 hr, Daphnia magna)
Degradability: Readily biodegradable under aerobic conditions
Bioaccumulation: Low potential; log Pow indicates unlikely to bioaccumulate
Mobility: Highly soluble in water; little tendency for soil adsorption
Other Environmental Effects: May cause pH changes in water bodies, toxic for aquatic life at high concentrations; avoid release to waterways

Disposal Considerations

Waste Treatment Methods: Dispose through licensed hazardous waste handler; incinerate with proper emission controls; hydrotreat contaminated packaging and equipment
Contaminated Packaging: Do not reuse containers; triple rinse before recycling/disposal; consult local hazardous waste regulations
Precautions: Do not discharge into drains, surface water, soil, or sewers; avoid evaporation into air
Regulatory Restrictions: Follow regional, national, and local requirements for disposal; comply with Resource Conservation and Recovery Act or equivalents

Transport Information

UN Number: UN 1604
UN Proper Shipping Name: Ethylenediamine
Transport Hazard Class: 8 (Corrosive), 3 (Flammable liquid)
Packing Group: I (high danger)
Labels: Corrosive, Flammable Liquid
Environmental Hazards: Not classified as a marine pollutant, but control spill risk
Transport in Bulk: Consult IMO/IBC code when transported in bulk by sea
Special Precautions: Secure packaging; emergency response information required in transit

Regulatory Information

TSCA Status (U.S.): Listed as a chemical substance
ECHA / REACH: Registered, subject to registration requirements and restrictions under Annex XVII
OSHA Hazard Class: Corrosive, Flammable Liquid
SARA 313: Ingredient subject to reporting under SARA Title III Section 313
WHMIS (Canada): Class B2 (Flammable), D1B (Toxic), E (Corrosive Material)
German Water Hazard Class: WGK 2 (hazard to waters)
Other International Regulations: Follows regional transport, workplace safety, and chemical management standards; refer to specific country or regional lists for full coverage