Material Safety Data Sheet for Methyl Isobutyl Ketone (MIBK)

Identification

Product Name: Methyl Isobutyl Ketone
Chemical Name: 4-Methyl-2-pentanone
Synonyms: Isobutyl methyl ketone, MIBK
CAS Number: 108-10-1
Recommended Use: Solvent in coatings, adhesives, chemical syntheses, cleaning fluids
Supplier: Chemical manufacturing companies, industrial solvent suppliers
Emergency Contact: Local emergency services, supplier’s emergency number

Hazard Identification

GHS Classification: Flammable liquid (Category 2), Acute toxicity (Category 4, inhalation), Eye irritation (Category 2A), Target organ toxicity (Category 3)
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor, causes serious eye irritation, may cause drowsiness or dizziness, harmful if inhaled
Precautionary Statements: Keep away from ignition sources, use explosion-proof equipment, avoid breathing vapors, use only outdoors or in well-ventilated areas, wear protective gloves and eye protection

Composition / Information on Ingredients

Chemical Name: Methyl Isobutyl Ketone
Concentration: ≥99%
CAS Number: 108-10-1
Impurities or Additives: May contain trace levels of water or residuals from production process

First Aid Measures

Inhalation: Remove person to fresh air immediately, keep at rest in a position comfortable for breathing, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and soap, consult physician if irritation continues
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention promptly
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical advice

Fire-Fighting Measures

Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, CO₂, water spray to cool containers
Unsuitable Media: Do not use direct water jet
Specific Hazards: Vapors may form explosive mixtures with air, containers exposed to fire may burst
Protective Equipment: Wear self-contained breathing apparatus, protective clothing, approach from upwind

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate zone, eliminate ignition sources, wear personal protective equipment
Environmental Precautions: Prevent entry into drains, waterways, or soil
Spill Response: Contain spill, absorb with inert material like sand, use non-sparking tools, place wastes in chemical waste container, dispose according to local regulations

Handling and Storage

Handling: Minimize vapor exposure, use only in well-ventilated areas, avoid contact with skin and eyes, ground and bond containers when transferring, avoid static discharge
Storage: Store in tightly closed containers, in a cool and well-ventilated place, keep away from incompatible materials like oxidizers and acids, protect from sunlight, store away from heat sources and spark-producing equipment

Exposure Controls and Personal Protection

Control Parameters: OSHA PEL: 100 ppm (410 mg/m³), ACGIH TLV: 20 ppm
Engineering Controls: Local exhaust ventilation, explosion-proof ventilation equipment
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), splash goggles or face shield, flame-resistant lab attire, respirators if ventilation inadequate, safety showers, emergency eye wash stations

Physical and Chemical Properties

Appearance: Clear, colorless liquid
Odor: Sweet, acetone-like
Odor Threshold: 0.1-0.5 ppm
pH: Not applicable
Melting Point: -84°C
Boiling Point: 116°C
Flash Point: 14°C (closed cup)
Evaporation Rate: 1.6 (butyl acetate = 1)
Flammability: Highly flammable
Lower/Upper Explosion Limits: 1.2% / 8.0% (v/v)
Vapor Pressure: 16 mmHg (20°C)
Vapor Density: 3.5 (air = 1)
Density: 0.8 g/cm³
Solubility in Water: 1.9g/100ml at 20°C
Partition Coefficient (n-octanol/water): 1.19
Autoignition Temperature: 460°C
Decomposition Temperature: Not determined
Viscosity: 0.63 cP at 25°C

Stability and Reactivity

Chemical Stability: Stable under normal processing and storage
Reactivity: Reacts violently with strong oxidizers, acids, bases
Conditions to Avoid: Heat, open flames, sparks, sources of static electricity
Hazardous Decomposition: Fumes of carbon monoxide and carbon dioxide
Incompatible Materials: Halogens, peroxides, nitric acid, sulfuric acid

Toxicological Information

Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Effects: Headache, dizziness, irritation, drowsiness, nausea at high concentrations
Chronic Effects: Prolonged inhalation may cause central nervous system depression, liver and kidney effects reported in laboratory studies
LD50 (Oral, rat): 2080 mg/kg
LC50 (Inhalation, rat): 8.2 mg/L (4h)
IARC Classification: Group 2B (possibly carcinogenic to humans)

Ecological Information

Ecotoxicity: Harmful to aquatic life, fish LC50 (96h): 505 mg/L (Pimephales promelas), daphnia EC50 (48h): 170 mg/L, algae EC50 (72h): 400 mg/L
Persistence and Degradability: Moderately biodegradable in water and soil
Bioaccumulation Potential: Low to moderate, log Kow 1.19
Mobility in Soil: High mobility
Other: Avoid contamination of surface and groundwater, do not discharge untreated to environment

Disposal Considerations

Disposal Methods: Dispose in accordance with local, regional, and national regulations
Recommended Treatment: Incineration in a licensed facility, after consultation with authorities
Contaminated Packaging: Triple rinse, recycle or dispose as hazardous waste
Do Not: Pour down drains, dump on land, or mix with general waste streams

Transport Information

UN Number: UN1245
Proper Shipping Name: Methyl isobutyl ketone
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: II
Label: Flammable Liquid
Marine Pollutant: No
Special Precautions: Keep container upright and tightly sealed, segregate from food and incompatible chemicals during transit

Regulatory Information

TSCA: Listed
REACH Registration: Registered, subject to certain restrictions
OSHA Hazards: Flammable, irritant
SARA Sections 311/312: Fire hazard, immediate health hazard
SARA Section 313: Listed for reporting
Canadian WHMIS: Classified as B2 (flammable liquid), D2A (toxic) and D2B (eye irritant)
EU Classification: F Highly Flammable, Xi Irritant, Xn Harmful